Salivary duct carcinoma sdc is a highgrade carcinoma with poor prognosis, especially among various salivary carcinomas. Salivary duct carcinoma sdc was originally described by kleinsasser and colleagues in 1968 as a salivary malignancy that histologically resembles ductal carcinoma of the breast. Salivary duct carcinoma is an uncommon malignant tumor that occurs mainly in the parotid gland of elderly men. This could be particularly important for aggressive salivary gland tumors, such as salivary duct carcinoma sdc. Salivary duct carcinoma sdc is a rare type of salivary malignancy which accounts for gland. Like other neoplasms of ductal origin, the prototype of which is mammary ductal carcinoma, sdc exhibits in traductal and infiltrating components.
Salivary gland carcinoma an overview sciencedirect topics. Smears are usually highly cellular, with the component cells lying either singly or in cohesive threedimensional clusters fig. Salivary duct carcinoma of the extraglandular segment of. Salivary duct carcinoma sdc is an uncommon, pathologically distinct entity characterized by its morphologic resemblance to ductal carcinoma of the breast and highly aggressive behavior. Our aim is to determine the prevalence of histologic variants micropapillary, basallike and androgen receptor ar expression in a large multiinstitutional series of sdc. Case report salivary duct carcinoma originating in the. Salivary duct carcinoma sdc is considered to be a distinct malignancy of the major salivary glands, because of its highly aggressive behaviour, and the high rate of recurrence, metastasis, and disease related death. Salivary duct carcinoma metastatic to inguinal lymph node. Current treatment options of surgery with or without radiation therapy provide limited benefit. Prognostic implication of histopathologic indicators in. She underwent chemotherapy and trastuzumab for palliation. Conventional chemotherapeutic agents have been utilized in the palliative setting with modest results. Ar status was determined by immunohistochemistry ihc.
Gingival metastasis from salivary duct carcinoma of the. Salivary gland cancer is a rare disease in which malignant cancer cells form in the tissues of the salivary glands. Salivary duct carcinoma sdc is a rare, aggressive malignancy that histologically resembles highgrade mammary duct carcinoma. Salivary ductal adenocarcinoma with complete response to. Because of the rarity of this entity, data verifying the association between histologic features and patient survival are limited. Bone marrow metastases in salivary duct carcinoma of the. Previously, little was known about outcomes of this disease due to its rarity. Signs of salivary gland cancer include a lump or trouble swallowing. It is predominantly seen in men and, generally, has a poor prognosis.
Salivary duct carcinoma sdc is a rare type of aggressive cancer that arises from the salivary glands. Salivary duct carcinoma sdc is a rare and aggressive malignancy with high mortality and poor response to treatment. In this study, we report a rare case of sdc of the parotid gland originating from an epithelialmyoepithelial carcinoma emc. Most sdcs were characterized by an apocrine phenotype and ar. Salivary duct carcinoma is an aggressive malignancy with a high mortality rate, which phenotypically resembles highgrade breast ductal carcinoma. Salivary duct carcinoma, oral cavity, gingiva introduction salivary duct carcinoma sdc is an uncommon tumor, accounting for % of all malignant salivary gland neoplasms, which was first described by kleinsasser et al. Case report breast metastasis of salivary duct carcinoma. Salivary duct carcinomas are associated with an appearance reminiscent of invasive ductal carcinoma of the breast. Publications home of jama and the specialty journals of.
Salivary duct carcinoma sdc is a prototypic aggressive salivary gland carcinoma. Oncocytic carcinoma salivary duct carcinoma adenocarcinoma, nos myoepithelial carcinoma carcinoma ex pleomorphic adenoma carcinosarcoma metastasizing pleomorphic adenoma squamous cell carcinoma small cell carcinoma large cell carcinoma lymphoepithelial carcinoma sialoblastoma 2005 who classification of malignant. Following surgery, she was diagnosed with disseminated bone marrow metastases. The salivary glands make saliva and release it into the mouth. For accreditation purposes, this protocol should be used for the following procedures and tumor types. Salivary duct carcinoma sdc is a rare malignancy that most commonly affects males in the fifth and sixth decades of life. Protocol for the examination of specimens from patients with carcinomas of the major salivary glands. Salivary ductal adenocarcinomas make up about 9% of malignant salivary gland tumors and occur mostly in men older than 50 years, with a peak incidence in the sixth and seventh decades. Invasive tumor, often aggressive, with glandular or ductal differentiation but no features characteristic of other specific types arch pathol lab med 2004. To investigate expression of the proteins involved in the retinoblastoma prb and p53 pathways, which control cell cycle. Sdc has a propensity to metastasize early to regional lymph nodes and distant sites, as well as.
Salivary duct carcinoma sdc is a rare and extremely aggressive salivary gland cancer. Importance salivary duct carcinoma is a rare, aggressive malignancy of the salivary glands. Combined androgen blockade for salivary gland carcinoma. Saliva has enzymes that help digest food and antibodies that help protect against infections of the mouth and throat. A case report of salivary duct carcinoma with distant metastasis diagnosed by fineneedle aspiration. It occurs more commonly in the parotid gland than in the submandibular or minor salivary glands 26. Combined androgen blockade with leuprorelin acetate and bicalutamide could be equally effective and less toxic than conventional chemotherapy for patients with androgen receptorpositive metastatic or locally advanced unresectable salivary gland carcinoma, according to a. Standard treatment is surgery to the primary tumour together with postoperative radiotherapy. Highgrade salivary duct carcinoma, which is already known to have a dismal outcome, was the most frequent subtype of highgrade salivary gland cancer in our series, but other pathologic types of highgrade salivary gland cancers also had a.
The 11 cases of salivary duct carcinoma which are included in this study occurred in older men mean age 56 years and were located in the parotid 7, submandibular salivary gland 2, and the minor salivary glands in the maxilla 2. Carcinoma expleomorphic adenoma pathology large tumors must have adequate sampling malignant component adjacent to benign often poorly differentiated carcinoma salivary duct carcinoma common infiltrative pattern remarkable cytological atypia scarring and sclerosis is common presence in pa requires additional evaluation carcinoma expleomorphic. A 71yearold japanese man presented with swelling of the right parotid region and a right facial nerve. June 2017 includes ptnm requirements from the 8th edition, ajcc staging manual. Their recognition is important particularly when the component tumours have different biological behaviours. An 81yearold woman with sdc underwent a total parotidectomy with facial nerve sacrifice and a neck dissection. Being exposed to certain types of radiation may increase the risk of salivary cancer. It is the most aggressive of salivary gland tumors and is histologically similar to highgrade, invasive ductal carcinoma of the breast. Salivary duct carcinoma an overview sciencedirect topics. Histology is similar to invasive ductal carcinoma of the breast specifically luminal androgen receptor ar positive subtype in situ areas frequently have comedo necrosis. In the past several years, much has been learned about.
Salivary duct carcinoma sdc is an extremely rare and aggressive type of salivary gland cancer with high morbidity and mortality. The cohort was next limited to patients with malignant histologic types using histology codes from the international classification of diseases for oncology, third edition for mec, acc, adenocarcinoma, salivary duct carcinoma, and acinic cell carcinoma etable in the supplement, grades 2 to 3 disease, and highrisk features stages t3t4 or. Salivary gland carcinoma sgc is a relatively rare cancer accounting for s alivary duct carcinoma sdc, which was described. The most common malignant major and minor salivary gland tumor is the mucoepidermoid carcinoma, which comprises about 10% of all salivary gland neoplasms and approximately 35% of malignant salivary gland neoplasms. Tests that examine the head, neck, and the inside of the mouth are. Patients commonly present with a fastgrowing form mass, often around. Hybrid tumours of the salivary gland are rare neoplasms that have been described only in the parotid and palate. This article will focus on some of the new advances in salivary gland tumor pathology that have a potential for clinical impact. Salivary duct carcinoma of the parotid gland originating. Salivary duct carcinoma sdc is a rare, aggressive salivary malignancy that is often diagnosed at an advanced stage.
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